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Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide Artical

Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang

Engineering 2015, Volume 1, Issue 4, Pages 500-505 doi: 10.15302/J-ENG-2015106

Abstract: antimicrobial agent, Acr₃-NLS, by conjugating hydrophobic acridines to the N-terminus of a nuclearlocalization sequence (NLS), a short cationic peptide.

Keywords： acridine nuclear localization sequence conjugate antimicrobial activity mechanism of action

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Sustainable Development of Chinses Nuclear Power

Zhao Renkai

Strategic Study of CAE 2000, Volume 2, Issue 10, Pages 33-41

Abstract:

Nuclear power is considered a sustainable energy resource, and it is a very important pillar for theIn the paper, the present status of nuclear power development in the world and China is described.problems commonly concerned with Chinese nuclear power development, such as uranium resources、nuclearsafety、radioactive wastes and localization of nuclear power in China are expounded and analyzed.to achieve localization、standardization、serialization The Fast Breeding Reactor plays a very important

Keywords： nuclear energy uranium resources nuclear safety radioactive westes localization

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Robotized machining of big work pieces: Localization of supporting heads

Wojciech SZYNKIEWICZ, Teresa ZIELIŃSKA, Włodzimierz KASPRZAK

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4, Pages 357-369 doi: 10.1007/s11465-010-0103-0

Abstract: A planner for a self adaptable and reconfigurable fixture system is proposed. The system is composed of mobile support agents that support thin sheet metal parts to minimize part dimensional deformation during drilling and milling operations. Compliant sheet metal parts are widely used in various manufacturing processes including automotive and aerospace industries. The main role of the planner is to generate an admissible plan of relocation of the mobile agents. It has to find the admissible locations for the supporting heads that provide continuous support in close proximity to the tool and trajectories of the mobile bases characterized by very high speeds during the relocation phases.

Keywords： fixture robot milling drilling

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Optimal localization of complex surfaces in CAD-based inspection

XU Jinting, LIU Weijun, SUN Yuwen

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4, Pages 426-433 doi: 10.1007/s11465-008-0068-4

Abstract: Complex surface inspection requires the optimal localization of the measured surface related to the designThis paper presents a new technique for solving the localization problem.The basic approach consists of two steps: 1) rough localization of the measured points to the designsurface based on curvature features, which can produce a good initial estimate for the optimal localization; 2) fine localization based on the least-square principle so that the deviation between the measured

Keywords： deviation comparison non-linear localization inspection

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Ant colony optimization for assembly sequence planning based on parameters optimization

Zunpu HAN, Yong WANG, De TIAN

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 2, Pages 393-409 doi: 10.1007/s11465-020-0613-3

Abstract: As an important part of product design and manufacturing, assembly sequence planning (ASP) has a considerabletypical NP-complete problem that requires effective methods to find the optimal or near-optimal assembly sequenceThe assembly constraints and rules guarantee to obtain a reasonable assembly sequence.SOS) and ant colony optimization (ACO) is proposed to calculate the optimal or near-optimal assembly sequenceSOS-ACO is also robust in identifying the best assembly sequence in nearly every experiment.

Keywords： assembly sequence planning ant colony optimization symbiotic organisms search parameter optimization

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Strain localization analyses of idealized sands in biaxial tests by distinct element method

Mingjing JIANG, Hehua ZHU, Xiumei LI,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 2, Pages 208-222 doi: 10.1007/s11709-010-0025-2

Abstract: This paper presents a numerical investigation on the strain localization of an idealized sand in biaxialexamined to illustrate the link between microscopic and macroscopic variables in the case of strain localizationThe study shows that strain localization of the granular material in the tests proceeds with localizations

Keywords： idealized sand strain localization numerical analyses distinct element method (DEM)

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Special issue: innovative nuclear energy technology

Frontiers in Energy 2021, Volume 15, Issue 4, Pages 791-792 doi: 10.1007/s11708-021-0794-4

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The research of grey clustering decision of assembly sequence based on petri net

Mo Qian,Luo Yi

Strategic Study of CAE 2008, Volume 10, Issue 11, Pages 65-68

Abstract: according to the intuitionistic graphics mode characteristics of petri net, and gets feasible assembly sequenceMost of factors influencing assembly sequence are certainly qualitative, fuzzy, non-numerical, assemblysequence is regarded as a gray system, and grey clustering decision method is adopted to evaluate feasibleassembly sequence.

Keywords： assembly sequence petri net grey clustering decision method

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Analysis of dispatching rules in a stochastic dynamic job shop manufacturing system with sequence-dependent

Pankaj SHARMA,Ajai JAIN

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4, Pages 380-389 doi: 10.1007/s11465-014-0315-9

Abstract:

Stochastic dynamic job shop scheduling problem with consideration of sequence-dependent setup times

Keywords： scheduling stochastic dynamic job shop sequence-dependent setup times dispatching rule simulation

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An old issue and a new challenge for nuclear reactor safety

F. D’AURIA

Frontiers in Energy 2021, Volume 15, Issue 4, Pages 854-859 doi: 10.1007/s11708-021-0729-0

Abstract: Nuclear reactor safety (NRS) and the branch accident analysis (AA) constitute proven technologies: theseamong the other things, long lasting research and operational experience in the area of water cooled nuclearWeaknesses became evident, noticeably in relation to nuclear fuel under high burn-up.

Keywords： large break loss of coolant accident (LBLOCA) nuclear reactor safety (NRS) licensing perspectives basisfor design of water cooled nuclear reactors (WCNR)

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunity for microbial genome. Consequently, considerable genetic diversity encoded by bacterial genomes and among the strains in the same species has been revealed. In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resulted in transformation and expedited the application of strategy and methodology for bacterial genome comparison used in dissection of infectious disease epidemics. Bacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirements of epidemiological study in disease control. In this review, we outline the significance and summarize the roles of bacterial genome sequencing in the context of bacterial disease control and prevention. We discuss the applications of bacterial genome sequencing in outbreak detection, source tracing, transmission mode discovery, and new epidemic clone identification. Wide applications of genome sequencing and data sharing in infectious disease surveillance networks will considerably promote outbreak detection and early warning to prevent the dissemination of bacterial diseases.

Keywords： genome sequencing genomic epidemiology bacteria surveillance infectious diseases

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Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes, which play crucial roles in lipid metabolism. However, little is known about the function of Lipin3 in triglyceride (TG) metabolism. Here, we identified a novel mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesity through whole-exome sequencing and Sanger sequencing. Functional studies revealed that the novel variant altered the half-life and stability of the Lipin3 protein. Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG metabolism. We found that Lipin3-heKO mice exhibited obvious obesity, HTG, and non-alcoholic fatty liver disorder. Mechanistic study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm. The increased expression of Lipin1 in cytosol may contribute to TG anabolism, and the decreased Lipin1 in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunction and reduced TG catabolism. Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG. We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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Let Nuclear Technology Create New Brilliancy forChina’s Sustainable Development

Du Xiangwan

Strategic Study of CAE 2008, Volume 10, Issue 1, Pages 9-11

Abstract:

This paper summarizes the development and application directions of nucleartechnology, including five aspects: nuclear technology and energy、nuclear technology and medicine,nuclearanalysis technology,nuclear radiation technology,astronautics and voyage´s nuclear power,etc.discusses the importance of them to sustainable development and generalizes the development trilogy of nuclear

Keywords： nuclear science nuclear technology nuclear engineering sustainable development

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Reliability prediction and its validation for nuclear power units in service

Jinyuan SHI,Yong WANG

Frontiers in Energy 2016, Volume 10, Issue 4, Pages 479-488 doi: 10.1007/s11708-016-0425-7

Abstract: In this paper a novel method for reliability prediction and validation of nuclear power units in serviceUsing these factors, the equivalent availability factor of nuclear power units in the following 3 yearsFurthermore, the reliability prediction method is validated using the nuclear power units in North AmericanIt is found that the relative errors of the predicted equivalent availability factors for nuclear powerfollowing 3 years, thus providing effective reliability management and maintenance optimization methods for nuclear

Keywords： nuclear power units in service reliability reliability prediction equivalent availability factors

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A Chinese–French Study on Nuclear Energy and the Environment Feature Article

Xiangeng Zhao, Qizhen Ye, Sébastien Candel, Dominique Vignon, Robert Guillaumont

Engineering 2023, Volume 26, Issue 7, Pages 159-172 doi: 10.1016/j.eng.2023.04.011

Abstract:

This article focuses on the environmental impact of nuclear energy andaddresses the following major environmental issues associated with nuclear power generation: ① controllingaccidents and their radioactive releases and; ④ improving nuclear safety to restrict its environmentalimpact and to contribute toward the public acceptance of nuclear energy.The annual effective radiation dose delivered to the public surrounding nuclear power plants under normal

Keywords： Nuclear energy Environmental impact Radwaste management Severe nuclear accidents Nuclear safety